Metastases following biopsy of oral carcinoma in hamsters and the role of local prebiopsy bleomycin.
Anticancer Res
; 28(4B): 2253-7, 2008.
Article
em En
| MEDLINE
| ID: mdl-18751403
ABSTRACT
BACKGROUND:
This animal study researches the effect of biopsy on metastasis of oral carcinoma. MATERIALS ANDMETHODS:
Sixty hamsters developed oral tumors after treatment with 9,10-dimethyl-1,2-benzanthracene and were then divided into six groups. Animals of groups 1 and 2 did not receive any treatment, while groups 3-6 were biopsied at the end of the 14th week and groups 5 and 6 also received a prebiopsy intratumoral injection of bleomycin. Animals of groups 1, 3, 5 and 2, 4, 6 were sacrificed at the 17th and 19th week respectively. Specimens of tumors, ipsilateral cervical lymph nodes, lungs and livers were obtained from all animals and histologically examined.RESULTS:
All animals developed oral squamous cell carcinomas. In group 4, four out of ten animals showed metastases to the cervical lymph nodes, and one out of four showed a distant metastasis to the lung.CONCLUSION:
Delay of treatment following biopsy can increase the risk of cervical lymph node metastases which can be reduced by an intratumoral administration of bleomycin.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biópsia
/
Bleomicina
/
Neoplasias Bucais
/
Carcinoma de Células Escamosas
/
Inoculação de Neoplasia
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article