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Synthesis and antibacterial activity of the C-7 side chain of 3-aminoquinazolinediones.
Hutchings, Kim M; Tran, Tuan P; Ellsworth, Edmund L; Watson, Brian M; Sanchez, Joseph P; Showalter, H D; Stier, Michael A; Shapiro, Martin; Themis Joannides, E; Huband, Michael; Nguyen, Dai Q; Maiti, Samarendra; Li, Tingsheng; Tailor, Jyoti; Thomas, George; Ha, Chan; Singh, Rajeshwar.
Afiliação
  • Hutchings KM; Pfizer Global Research and Development, Michigan Laboratories, Ann Arbor Campus, 2800 Plymouth Road, Ann Arbor, MI 48105, USA. kim.hutchings@astrazeneca.com
Bioorg Med Chem Lett ; 18(18): 5087-90, 2008 Sep 15.
Article em En | MEDLINE | ID: mdl-18752951
ABSTRACT
A novel series of bacterial topoisomerase (3-aminoquinazolinediones) inhibitors are described. The side-chain SAR against Gram-positive and Gram-negative organisms as well as DNA gyrase activity is reported.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinazolinonas / Inibidores da Topoisomerase II / Bactérias Gram-Negativas / Bactérias Gram-Positivas / Antibacterianos Idioma: En Ano de publicação: 2008 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinazolinonas / Inibidores da Topoisomerase II / Bactérias Gram-Negativas / Bactérias Gram-Positivas / Antibacterianos Idioma: En Ano de publicação: 2008 Tipo de documento: Article