Gas chromatographic separation of methoxylated polychlorinated biphenyl atropisomers.
J Chromatogr A
; 1207(1-2): 146-54, 2008 Oct 17.
Article
em En
| MEDLINE
| ID: mdl-18760792
ABSTRACT
Several polychlorinated biphenyls (PCBs) and their hydroxylated metabolites display axial chirality. Here we describe an enantioselective, gas chromatographic separation of methylated derivatives of hydroxylated (OH-)PCB atropisomers (MeO-PCB) using a chemically bonded beta-cyclodextrin column (Chirasil-Dex). The atropisomers of several MeO-PCBs could be separated on this column with resolutions ranging from 0.42 to 0.87 under isothermal or temperature-programmed conditions. In addition, the enantiomeric fraction of OH-PCB 136 metabolites was determined in male and female rats treated with racemic PCB 136. The methylated derivatives of two OH-PCB 136 metabolites showed an enantiomeric enrichment in liver tissue, whereas PCB 136 itself was near racemic.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromatografia Gasosa
/
Bifenilos Policlorados
/
Fígado
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article