PNA-peptide conjugates as intracellular gene control agents.
Nucleic Acids Symp Ser (Oxf)
; (52): 31-2, 2008.
Article
em En
| MEDLINE
| ID: mdl-18776238
ABSTRACT
Serum-stabilized PNA-internalization peptides (Pip) conjugated to PNA complementary to the 705 aberrant beta-globin splice site are able to correct splicing and increase luciferase production in Hela pLuc705 cells with sub microM EC(50) in the absence of a transfection agent. Inhibition of microRNA-122 in liver cells is achieved by treatment with complementary PNA containing just a few attached Lys residues, again without need of a transfection agent.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Splicing de RNA
/
Ácidos Nucleicos Peptídicos
/
MicroRNAs
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article