[Open food challenge with milk, egg white and wheat].
Arerugi
; 57(8): 1043-52, 2008 Aug.
Article
em Ja
| MEDLINE
| ID: mdl-18781109
ABSTRACT
BACKGROUND:
A method for open food challenge test to determine food allergy has not been established in an evidence-based manner.METHODS:
We conducted an analysis of 438 open food challenges of raw milk (n=133, mean age 2.7+/-1.9 years), boiled egg white (n=216, 2.8+/-2.1 years) or udon noodles (n=89, 2.7+/-1.7 years) for the patients aged 1 year or more. Doses were increased (trace amounts, 1 g, 2 g, 5 g, 10 g, 20-30 g) every 20 minutes.RESULTS:
In total, 151 (38.5%) of food challenges were positive. The positive rates of milk, egg and wheat challenges were 35.8%, 42.4% and 33.3%, respectively. Of these, 76.2%, 32.5%, 27.8% and 0.7% had, respectively, skin, respiratory, gastrointestinal and cardiovascular symptoms. Although the prevalence of positive challenge increased with level of specific IgE, it did not correlate with the threshold amount of positive food challenge or the severity of symptoms. Among the challenge positive patients, 10.6% required injection of antihistamines, corticosteroids or adrenalines for the treatment of the symptoms.CONCLUSIONS:
This challenge protocol seemed to be appropriate and safe.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Triticum
/
Leite
/
Clara de Ovo
/
Hipersensibilidade Alimentar
Tipo de estudo:
Guideline
/
Risk_factors_studies
Limite:
Animals
/
Child, preschool
/
Humans
/
Infant
Idioma:
Ja
Ano de publicação:
2008
Tipo de documento:
Article