Induction of apoptosis by KI0477959 through activation of caspase-3 in human leukemia cell line, HL-60 cells.
Int J Neurosci
; 118(10): 1384-99, 2008 Oct.
Article
em En
| MEDLINE
| ID: mdl-18788024
ABSTRACT
KI0477959 (Herbkines) has been used for the purpose of development of physical strength in wasting diseases, like cancer. In the present study, apoptosis-inducing activities of butanol fraction of KI0477959 were studied in human leukemia cell line, HL-60 cells. KI0477959 increased cytotoxicity but had less effect on human peripheral blood mononuclear cells. KI0477959-induced apoptosis was accompanied by activation of caspase-3 and specific proteolytic cleavage of poly-ADP-ribose polymerase. Increased apoptosis was reduced by treatment with p38 and extracellular signal-regulated protein kinase (ERK) inhibitors. These results suggest that KI0477959 induces apoptosis through activation of caspase-3, p38, and ERK in HL-60 cells.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Medicamentos de Ervas Chinesas
/
Extratos Vegetais
/
Apoptose
/
Caspase 3
Limite:
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article