Differences between embryonic and adult Torpedo acetylcholine receptor gamma subunit.
FEBS Lett
; 288(1-2): 222-6, 1991 Aug 19.
Article
em En
| MEDLINE
| ID: mdl-1879556
ABSTRACT
Antibodies to a synthetic peptide corresponding to residues 346-359 of the Torpedo acetylcholine receptor (AChR) gamma subunit, were employed to compare the adult and embryonic receptor. This peptide contains a consensus phosphorylation site for cAMP-dependent protein kinase (PKA). The anti-peptide antibodies discriminated between adult and embryonic AChRs, and reacted preferentially with the adult gamma form. These observed immunological differences did not seem to stem from different phosphorylation states. Our results suggest that the embryonic Torpedo AChR may have a gamma-like subunit that differs from the known adult form of this subunit, at least in the specific region that contains the phosphorylation site for PKA.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Torpedo
/
Receptores Colinérgicos
Limite:
Animals
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article