Neuroimaging and cognitive changes during déjà vu.
Epilepsy Behav
; 14(1): 190-6, 2009 Jan.
Article
em En
| MEDLINE
| ID: mdl-18804184
ABSTRACT
OBJECTIVE:
The cause or the physiological role of déjà vu (DV) in healthy people is unknown. The pathophysiology of DV-type epileptic aura is also unresolved. Here we describe a 22-year-old woman treated with deep brain stimulation (DBS) of the left internal globus pallidus for hemidystonia. At certain stimulation settings, DBS elicited reproducible episodes of DV.METHODS:
Neuropsychological tests and single-photon-emission computed tomography (SPECT) were performed during DBS-evoked DV and during normal DBS stimulation without DV.RESULTS:
SPECT during DBS-evoked DV revealed hyperperfusion of the right (contralateral to the electrode) hippocampus and other limbic structures. Neuropsychological examinations performed during several evoked DV episodes revealed disturbances in nonverbal memory.CONCLUSION:
Our results confirm the role of mesiotemporal structures in the pathogenesis of DV. We hypothesize that individual neuroanatomy and disturbances in gamma oscillations or in the dopaminergic system played a role in DBS-elicited DV in our patient.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cognição
/
Déjà Vu
/
Epilepsia
/
Globo Pálido
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article