CD8+ regulatory T cells-A distinct T-cell lineage or a transient T-cell phenotype?
Hum Immunol
; 69(11): 696-9, 2008 Nov.
Article
em En
| MEDLINE
| ID: mdl-18817824
ABSTRACT
Regulation of the immune system is fundamental for proper immune function and homeostasis. In the periphery, regulatory T cells provide self-tolerance and protect the host from harmful autoreactive T cells. Regulatory T cells are also involved in the pathogenesis of chronic viral infectious diseases and cancer. Both the CD4(+) and the CD8(+) T cell compartments contain regulatory T cells. Although various CD4(+) regulatory T-cell subsets represent the best characterized regulatory T-cell populations, CD8(+) regulatory T cells also have strong immunosuppressive properties and are involved in the pathogenesis of various clinical conditions. In this review, we will discuss the phenotypic and functional characteristics of CD8(+) regulatory T cells in comparison to CD4(+) regulatory T cells.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Viroses
/
Subpopulações de Linfócitos T
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Tolerância a Antígenos Próprios
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Linfócitos T CD8-Positivos
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Homeostase
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Neoplasias
Limite:
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article