Catalytic site-selective synthesis and evaluation of a series of erythromycin analogs.
Bioorg Med Chem Lett
; 18(22): 6007-11, 2008 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-18819795
ABSTRACT
The generation of a series of analogs of erythromycin A (EryA, 2) is described. In this study, we compared two peptide-based catalysts-one originally identified from a catalyst screen (5) and its enantiomer (ent-5)-for the selective functionalization of EryA. The semi-synthetic analogs were subjected to MIC evaluation with two bacterial strains and compared to unfunctionalized EryA.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Eritromicina
/
Enterococcus faecalis
/
Antibacterianos
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article