Modulation of the antitumor immune response by complement.
Nat Immunol
; 9(11): 1225-35, 2008 Nov.
Article
em En
| MEDLINE
| ID: mdl-18820683
ABSTRACT
The involvement of complement-activation products in promoting tumor growth has not yet been recognized. Here we show that the generation of complement C5a in a tumor microenvironment enhanced tumor growth by suppressing the antitumor CD8(+) T cell-mediated response. This suppression was associated with the recruitment of myeloid-derived suppressor cells into tumors and augmentation of their T cell-directed suppressive abilities. Amplification of the suppressive capacity of myeloid-derived suppressor cells by C5a occurred through regulation of the production of reactive oxygen and nitrogen species. Pharmacological blockade of the C5a receptor considerably impaired tumor growth to a degree similar to the effect produced by the anticancer drug paclitaxel. Thus, our study demonstrates a therapeutic function for complement inhibition in the treatment of cancer.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T Citotóxicos
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Complemento C5a
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Terapia de Imunossupressão
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Receptor da Anafilatoxina C5a
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Neoplasias
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article