Bioluminescence imaging of hepatitis B virus enhancer and promoter activities in mice.
FEBS Lett
; 582(23-24): 3552-6, 2008 Oct 15.
Article
em En
| MEDLINE
| ID: mdl-18822287
ABSTRACT
By bioluminescence imaging and hydrodynamic gene transfer technology, the activities of hepatitis B virus (HBV) promoters and the effects of HBV enhancers on these promoters in mice under true physiological conditions have been assessed. Our studies reveal that either of the two HBV enhancers can stimulate HBV major promoter activity in hepa 1-6 cells (in vitro) and in mouse liver (in vivo), and the enhancer effects on the three promoters (S1, S2 and X promoter) are markedly greater in vivo than in vitro. The two HBV enhancers have no cooperative action on HBV promoters in vitro or in vivo.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regulação Viral da Expressão Gênica
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Vírus da Hepatite B
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Elementos Facilitadores Genéticos
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Regiões Promotoras Genéticas
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Fígado
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article