Quantifying the impact of non-adherence to drug therapy: a technical note concerning an application of a branch and bound algorithm.
Health Care Manag Sci
; 11(3): 302-5, 2008 Sep.
Article
em En
| MEDLINE
| ID: mdl-18826008
ABSTRACT
Pharmacokinetic models typically rely on a key assumption that patients take their medication as prescribed, whereas this is often not the case. We present a branch and bound algorithm that can be used to estimate the time-varying probability that, given a specified pattern of nonadherence to a prescribed regimen, a patient receives no therapeutic benefit from treatment. Use of this algorithm is a much faster method for obtaining this probability than exhaustive computation of the relevant probability distribution. The use of this algorithm to assess, in quantitative terms, the impact of non-adherence on the effectiveness of treatment provides a rational basis for evaluating the potential harm to patients.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Algoritmos
/
Preparações Farmacêuticas
/
Recusa do Paciente ao Tratamento
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article