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Successful rescue therapy with a darunavir/ritonavir and etravirine antiretroviral regimen in a child with vertically acquired multidrug-resistant HIV-1.
Viganò, Alessandra; Meroni, Luca; Marchetti, Giulia; Vanzulli, Angelo; Giacomet, Vania; Fasan, Silvia; Pradella, Andrea; Cerini, Chiara; Zuccotti, Gian V.
Afiliação
  • Viganò A; Luigi Sacco Hospital, University of Milan, Milan, Italy. alessandra.vigano@unimi.it
Antivir Ther ; 13(6): 839-43, 2008.
Article em En | MEDLINE | ID: mdl-18839785
An increasing prevalence of antiretroviral therapy (ART) resistance in ART-experienced and ART-naive pregnant women has been reported. Some studies suggest that antiretroviral drug-resistant viruses might have decreased replication capacity and transmissibility. However, cases of perinatal transmission of multidrug-resistant HIV type-1 (HIV-1) have been described. Here, we report the case of one child with vertically-acquired multidrug-resistant HIV-1 and the outcome of a rescue therapy with a darunavir/ritonavir- and etravirine-containing antiretroviral regimen. During the 15 months of therapy, the child showed clinical improvement, including no side effects, persistent suppression of viral replication and a great increase in CD4+ T-cell count. Paediatric HIV specialists should be prepared to manage a small, but increasing, number of babies with a 'nightmare' multidrug-resistant virus with no available treatment options. The use of experimental agents might become a compelling issue in vertically HIV-infected children born in the era of highly active ART.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Infecciosas na Gravidez / Piridazinas / Sulfonamidas / Infecções por HIV / HIV-1 / Ritonavir / Fármacos Anti-HIV / Farmacorresistência Viral Múltipla Tipo de estudo: Risk_factors_studies Limite: Female / Humans / Male / Newborn / Pregnancy Idioma: En Ano de publicação: 2008 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Infecciosas na Gravidez / Piridazinas / Sulfonamidas / Infecções por HIV / HIV-1 / Ritonavir / Fármacos Anti-HIV / Farmacorresistência Viral Múltipla Tipo de estudo: Risk_factors_studies Limite: Female / Humans / Male / Newborn / Pregnancy Idioma: En Ano de publicação: 2008 Tipo de documento: Article