Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers.
Proc Natl Acad Sci U S A
; 105(42): 16224-9, 2008 Oct 21.
Article
em En
| MEDLINE
| ID: mdl-18852474
ABSTRACT
We have performed a genome-wide analysis of copy number changes in breast and colorectal tumors using approaches that can reliably detect homozygous deletions and amplifications. We found that the number of genes altered by major copy number changes, deletion of all copies or amplification to at least 12 copies per cell, averaged 17 per tumor. We have integrated these data with previous mutation analyses of the Reference Sequence genes in these same tumor types and have identified genes and cellular pathways affected by both copy number changes and point alterations. Pathways enriched for genetic alterations included those controlling cell adhesion, intracellular signaling, DNA topological change, and cell cycle control. These analyses provide an integrated view of copy number and sequencing alterations on a genome-wide scale and identify genes and pathways that could prove useful for cancer diagnosis and therapy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Neoplasias Colorretais
/
Amplificação de Genes
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Homozigoto
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article