Ki-67 and bromodeoxyuridine labeling of human choroidal melanoma cells.
Curr Eye Res
; 10(5): 479-84, 1991 May.
Article
em En
| MEDLINE
| ID: mdl-1889233
ABSTRACT
Understanding tumor growth patterns has implications for prognosis as well as for response and susceptibility to treatment. The antibody Ki-67 was used as a marker of cycling cells and bromodeoxyuridine (BrdUrd) was used as a marker of proliferating cells to characterize the cycling and proliferative rates of cells from human choroidal melanoma. The BrdUrd labeling indices varied from 0-1.1% and the Ki-67 labeling indices ranged from 0-3.0.3%. Linear regression modeling showed good correlation defined by the equation Ki-67 index = 0.237 + 1.63 x BrdUrd labeling index with r = 0.919. Correlations between these indices and clinical and histologic parameters were not significant.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bromodesoxiuridina
/
Proteínas Nucleares
/
Biomarcadores Tumorais
/
Neoplasias da Coroide
/
Melanoma
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article