A role for Th17 cells in the immunopathogenesis of atopic dermatitis?

Cesare, Antonella Di; Meglio, Paola Di; Nestle, Frank O

Cesare, Antonella Di; Meglio, Paola Di; Nestle, Frank O.

Afiliação

Cesare AD; St. John's Institute of Dermatology, King's College London School of Medicine and NIHR Biomedical Research Centre, London, United Kingdom; Department of Dermatology, University of L'Aquila L'Aquila, Italy.
Meglio PD; St. John's Institute of Dermatology, King's College London School of Medicine and NIHR Biomedical Research Centre, London, United Kingdom.
Nestle FO; St. John's Institute of Dermatology, King's College London School of Medicine and NIHR Biomedical Research Centre, London, United Kingdom. Electronic address: frank.nestle@kcl.ac.uk.

J Invest Dermatol ; 128(11): 2569-2571, 2008 Nov.

Article em En | MEDLINE | ID: mdl-18927538

ABSTRACT

ABSTRACT

Atopic dermatitis (AD) is a common inflammatory skin disease. Both epidermal barrier dysfunction and immunodysregulation are suggested to influence the pathogenesis of AD. AD has been considered a paradigmatic T helper cell (Th) 2-mediated disease, with a switch to a Th1 cell environment during the chronic phase of the disease. Previously unreported findings now suggest a possible role for Th17 cells as well.

Assuntos

Dermatite Atópica/etiologia; Dermatite Atópica/imunologia; Interleucina-17/metabolismo; Linfócitos T Auxiliares-Indutores/metabolismo; Linfócitos T CD4-Positivos/imunologia; Progressão da Doença; Humanos; Índice de Gravidade de Doença; Células Th1/metabolismo; Células Th2/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T Auxiliares-Indutores / Interleucina-17 / Dermatite Atópica Limite: Humans Idioma: En Ano de publicação: 2008 Tipo de documento: Article

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