Loss of ephrin-A5 function disrupts lens fiber cell packing and leads to cataract.
Proc Natl Acad Sci U S A
; 105(43): 16620-5, 2008 Oct 28.
Article
em En
| MEDLINE
| ID: mdl-18948590
ABSTRACT
Cell-cell interactions organize lens fiber cells into highly ordered structures to maintain transparency. However, signals regulating such interactions have not been well characterized. We report here that ephrin-A5, a ligand of the Eph receptor tyrosine kinases, plays a key role in lens fiber cell shape and cell-cell interactions. Lens fiber cells in mice lacking ephrin-A5 function appear rounded and irregular in cross-section, in contrast to their normal hexagonal appearance in WT lenses. Cataracts eventually develop in 87% of ephrin-A5 KO mice. We further demonstrate that ephrin-A5 interacts with the EphA2 receptor to regulate the adherens junction complex by enhancing recruitment of beta-catenin to N-cadherin. These results indicate that the Eph receptors and their ligands are critical regulators of lens development and maintenance.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Catarata
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Comunicação Celular
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Receptor EphA2
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Efrina-A5
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Cristalino
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article