Highly (E)-selective Wadsworth-Emmons reactions promoted by methylmagnesium bromide.

Claridge, Timothy D W; Davies, Stephen G; Lee, James A; Nicholson, Rebecca L; Roberts, Paul M; Russell, Angela J; Smith, Andrew D; Toms, Steven M

Claridge, Timothy D W; Davies, Stephen G; Lee, James A; Nicholson, Rebecca L; Roberts, Paul M; Russell, Angela J; Smith, Andrew D; Toms, Steven M.

Afiliação

Claridge TD; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.

Org Lett ; 10(23): 5437-40, 2008 Dec 04.

Article em En | MEDLINE | ID: mdl-18975957

ABSTRACT

ABSTRACT

An experimentally simple protocol for the very highly (E)-selective Wadsworth-Emmons reaction [(E)(Z) selectivities in excess of 1801 in some cases] of a range of straight-chain and branched aliphatic, substituted aromatic, and base-sensitive aldehydes via reaction with an alkyl diethylphosphonoacetate and MeMgBr is reported.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2008 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2008 Tipo de documento: Article