Loss of the mitochondrial nucleoid protein, Abf2p, destabilizes repetitive DNA in the yeast mitochondrial genome.
Genetics
; 181(1): 331-4, 2009 Jan.
Article
em En
| MEDLINE
| ID: mdl-19015543
ABSTRACT
Loss of Abf2p, an abundant mitochondrial nucleoid-associated protein, results in increased mitochondrial frameshifts and direct-repeat mediated deletions but has no effect on the rate of mitochondrial point mutations. The instability of repeated sequences in this strain may be linked to the loss of mitochondrial DNA in abf2-Delta strains.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Saccharomyces cerevisiae
/
Fatores de Transcrição
/
DNA Mitocondrial
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Sequências Repetitivas de Ácido Nucleico
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Instabilidade Genômica
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Proteínas de Ligação a DNA
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Genoma Mitocondrial
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article