[Synthesis and characterization of thermosensitive hydrogel based on PEG-PCL-PEG block copolymers].
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
; 25(5): 1121-5, 2008 Oct.
Article
em Zh
| MEDLINE
| ID: mdl-19024459
ABSTRACT
In this paper, a series of low-molecular-weight PEG-PCL-PEG triblock copolymers were successfully synthesized by ring-opening polymerization method, and were characterized using 1H-NMR and FTIR. The aqueous solution displayed specific thermosensitive gel-sol transition when the concentration was above corresponding critical gel concentration (CGC). The gel-sol phase diagram was recorded using test tube-inverting method, which was depended on the hydrophilic/hydrophobic balance in macromolecular structure, as well as heating history. As a result, the gel-sol transition temperature range could be altered, which might be very useful for its application as injectable drug delivery system.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poliésteres
/
Polietilenoglicóis
/
Materiais Biocompatíveis
/
Portadores de Fármacos
/
Hidrogel de Polietilenoglicol-Dimetacrilato
Idioma:
Zh
Ano de publicação:
2008
Tipo de documento:
Article