Caspases and IAPs: a dance of death ensures cell survival.
Mol Cell
; 32(4): 462-3, 2008 Nov 21.
Article
em En
| MEDLINE
| ID: mdl-19026777
ABSTRACT
In this issue of Molecular Cell, Ditzel et al. (2008) show that DIAP1 polyubiquitinates DRONC, DCP-1, and drICE, leading to their nondegradative inactivation. Surprisingly, activation of DIAP1 requires caspase-mediated cleavage, revealing an elegant feedback mechanism by which caspases regulate their own fate.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Apoptose
/
Caspases
/
Proteínas Inibidoras de Apoptose
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article