Your browser doesn't support javascript.
loading
High-dose chemotherapy with autologous stem cell rescue in stage IIIB inflammatory breast cancer.
Yalamanchili, Kiran; Lalmuanpuii, Judy; Waheed, Faisal; Farjami, Sassan; Kancherla, Ram; Qureshi, Zeeshan; Hoang, Albert; Khaled, Yusuf; Lake, Diana; Puccio, Carmello; Chun, Hoo G; Seiter, Karen; Ahmed, Tauseef.
Afiliação
  • Yalamanchili K; Division of Oncology and Hematology, New York Medical College and Zalmen A. Arlin Cancer Institute, Westchester Medical Center, Valhalla, NY, USA.
Anticancer Res ; 28(5B): 3139-42, 2008.
Article em En | MEDLINE | ID: mdl-19031971
BACKGROUND: Despite the advances in breast cancer care, inflammatory breast cancer (IBC) has a poor prognosis. The purpose of this study was to determine the efficacy of high-dose chemotherapy (HDCT) with thiotepa, mitoxantrone and carboplatin (TMJ regimen) in women with TNM stage IIIB IBC. PATIENTS AND METHODS: Between 1991 and 1998, twenty-eight patients with stage IIIB IBC underwent an autologous stem cell transplant after undergoing chemotherapy, surgery and/or radiation. Stem cells were collected from the bone marrow and periphery after mobilization with growth factors. Patients received thiotepa 250 mg/m2 once daily i.v. for 3 days, mitoxantrone 40 mg/m2 for 1 day and carboplatin 333 mg/m2 once daily i.v. for 3 days as the conditioning regimen for the HDCT. Radiation therapy and tamoxifen was offered to patients post HDCT if appropriate. Progression-free survival and overall survival was assessed over a 15-year period. RESULTS: At the time of last follow-up in May, 2007, sixteen patients had relapsed. The median overall survival was 49.5 months. The median progression free survival was 40 months. There were no transplant-related deaths. Mucositis and infections were the major side-effects. These results show that HDCT with the TMJ regimen is safe and effective in patients with stage IIIB IBC.
Assuntos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Protocolos de Quimioterapia Combinada Antineoplásica / Transplante de Células-Tronco Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Middle aged Idioma: En Ano de publicação: 2008 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Protocolos de Quimioterapia Combinada Antineoplásica / Transplante de Células-Tronco Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Middle aged Idioma: En Ano de publicação: 2008 Tipo de documento: Article