Altered pulmonary interleukin-6 signaling in preterm infants developing bronchopulmonary dysplasia.
Exp Lung Res
; 34(10): 694-706, 2008 Dec.
Article
em En
| MEDLINE
| ID: mdl-19085566
ABSTRACT
Interleukin (IL)-6 signaling depends on the soluble IL-6 receptor (sIL-6R) and the soluble glycoprotein 130 (sgp130). To investigate the impact of IL-6 signaling on the pathogenesis of bronchopulmonary dysplasia of prematurity (BPD), IL-6, sIL-6R, and sgp130 were measured by enzyme-linked immunosorbent assay (ELISA) technique in tracheal aspirates of mechanically ventilated preterm infants. Infants developing BPD showed increased concentrations of IL-6, sIL-6R, and sgp-130 in their first week of life. These infants also had significantly higher molar ratios for IL-6/sIL-6R and IL-6/sgp130. The authors conclude that altered interleukin-6 signaling via the soluble receptors sIL-6R and sgp130 may play an important role in pulmonary inflammation of preterm infants.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Traqueia
/
Displasia Broncopulmonar
/
Transdução de Sinais
/
Interleucina-6
Tipo de estudo:
Etiology_studies
Limite:
Female
/
Humans
/
Male
/
Newborn
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article