Your browser doesn't support javascript.
loading
[Continuous hyperthermic peritoneal perfusion (CHPP) therapy in advanced gastric cancer].
Suzuki, H; Miyagishima, K; Gasa, F; Hakamada, K; Seino, K; Hada, R; Mikami, Y; Sugiyama, Y; Konn, M; Ono, K.
Afiliação
  • Suzuki H; Second Dept. of Surgery, Hirosaki University School of Medicine.
Gan To Kagaku Ryoho ; 18(11): 1769-72, 1991 Aug.
Article em Ja | MEDLINE | ID: mdl-1908652
In CHPP therapy for advanced gastric cancer, a perfusate containing 20 mg CDDP and 8 mg MMC in 1,000 ml physiologic saline warmed at 47 degrees C was infused at a constant rate of 200 ml/min into the pouch of Douglas. The intraperitoneal temperature at the supra-pancreatic region was around 39.0 degrees C. To obtain a more stable and higher intraperitoneal temperature, the infusing rate was increased to 400 ml/min. This yielded a 3 degrees C higher temperature (42 degrees C) at the same measuring site. However, the temperature recorded at various intraperitoneal sites did not always reach such an effective range. The maximal plasma concentrations of MMC determined during CHPP at the 200 and 400 ml/min infusion were 0.09 +/- 0.03 and 0.11 +/- 0.03 microgram/ml, and those of CDDP 1.6 +/- 0.4 and 1.7 +/- 0.3 microgram/ml, respectively, all of which were not significantly different. When an intraperitoneal dosage of 20 mg MMC was given to 3 patients, the portal venous blood, at 10 min after the administration, produced a 1.7 times higher concentration of the agent than did the peripheral venous blood. This discrepancy between the two concentrations was much smaller than found by other investigators in animal experiments.
Assuntos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Protocolos de Quimioterapia Combinada Antineoplásica / Hipertermia Induzida Limite: Adult / Female / Humans / Male / Middle aged Idioma: Ja Ano de publicação: 1991 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Protocolos de Quimioterapia Combinada Antineoplásica / Hipertermia Induzida Limite: Adult / Female / Humans / Male / Middle aged Idioma: Ja Ano de publicação: 1991 Tipo de documento: Article