[AZF microdeletions are not related with recurrent spontaneous abortion].

ABSTRACT

OBJECTIVE: To study the relationship between azoospermia factor (AZF) microdeletions of the Y-chromosome and recurrent spontaneous abortion. METHODS: We collected 26 chorionic villus samples from abortive male embryos and 51 blood samples from the husbands whose wives had recurrent spontaneous abortion, extracted genomic DNA from the samples and detected 12 STSs in the AZFa, AZFb and AZFc regions of Yq11.2 by amplification multiplex PCR. RESULT: AZF microdeletions were found neither in the chorionic villus samples nor in the blood samples. CONCLUSION: There is no relationship between AZF microdeletions and recurrent spontaneous abortion.