A new type of tripropeptin with anteiso-branched chain fatty acid from Lysobacter sp. BMK333-48F3.
J Antibiot (Tokyo)
; 61(9): 577-82, 2008 Sep.
Article
em En
| MEDLINE
| ID: mdl-19160527
ABSTRACT
Branched chain amino acids are often utilized as the precursors of many lipid-containing bacterial secondary metabolites. The effect of isoleucine on the composition of the mixture of cyclic lipopeptide antibiotics, tripropeptins from Lysobacter sp. BMK333-48F3 was evaluated. As expected, a novel tripropeptin analog with an anteiso-branched fatty acid was produced. The new compound, TPPaiC shows potent antibacterial activity against Gram-positive bacteria including MRSA and VRE. On the other hand, no increase was observed in the production of other tripropeptins by the addition of isoleucine.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Depsipeptídeos
/
Lysobacter
/
Ácidos Graxos
/
Antibacterianos
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article