Seizure control and side-effect profile after switching adult epileptic patients from standard to extended-release divalproex sodium.
Clin Neurol Neurosurg
; 111(5): 437-41, 2009 Jun.
Article
em En
| MEDLINE
| ID: mdl-19181439
ABSTRACT
OBJECTIVES:
To assess changes in seizure frequency, medication side-effects (especially tremor) and formulation preference after switching patients overnight from immediate-release to extended-release divalproex sodium.METHODS:
Prospective evaluation of consecutive adult outpatients at an urban public hospital who were followed for 6 months after switching drug formulations. Seizure frequency was estimated from patient self-reports. Medication side-effects were monitored with a structured interview (tremor, fatigue, GI upset, hair loss), physician exam (nystagmus, tremor), a drawing test (tremor) and a specific 25-item questionnaire assessing the impact of tremor on activities of daily living.RESULTS:
Forty-seven patients were included in the study but six patients were either lost to follow-up or had insufficient data. Seizure frequency and side-effect profile did not change significantly after switching drug formulations. However, patients had significant subjective improvement in their tremor with the extended-release formulation as assessed by the 25-item questionnaire (p=0.009 at 3 months and p=0.04 at 6 months); other measures of tremor severity showed no change during the 6-month follow-up period. Most patients (71%) preferred the extended-release formulation.CONCLUSION:
Patients with epilepsy can be switched overnight from standard to extended-release divalproex sodium, without significant change in seizure frequency and drug side-effect profile. Most patients prefer the extended-release formulation, in part due to subjective decrease in tremor during daily activities.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Convulsões
/
Ácido Valproico
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Epilepsia
/
Anticonvulsivantes
Tipo de estudo:
Etiology_studies
/
Incidence_studies
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Observational_studies
/
Prognostic_studies
/
Qualitative_research
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article