Age-related grey matter volume correlates of response inhibition and shifting in attention-deficit hyperactivity disorder.
Br J Psychiatry
; 194(2): 123-9, 2009 Feb.
Article
em En
| MEDLINE
| ID: mdl-19182173
ABSTRACT
BACKGROUND:
Children with attention-deficit hyperactivity disorder (ADHD) have difficulties with executive function and impulse control which may improve with age.AIMS:
To map the brain correlates of executive function in ADHD and determine age-related changes in reaction times and brain volumes.METHOD:
Attention-deficit hyperactivity disorder and control groups were compared on the change task measures of response inhibition (stop signal reaction time, SSRT) and shifting (change response reaction time, CRRT). Voxel-wise magnetic resonance imaging (MRI) correlations of reaction times and grey matter volume were determined, along with bivariate correlations of reaction times, brain volumes and age.RESULTS:
Individuals in the ADHD group had longer SSRTs and CRRTs. Anterior cingulate, striatal and medial temporal volumes highly correlated with SSRT. Striatal and cerebellar volumes strongly correlated with CRRT. Older children had faster reaction times and larger regional brain volumes. In controls, orbitofrontal, medial temporal and cerebellar volumes correlated with CRRT but not SSRT. Neither reaction times nor regional brain volumes were strongly age-dependent.CONCLUSIONS:
Our evidence supports delayed brain maturation in ADHD and implies that some features of ADHD improve with age.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tempo de Reação
/
Transtorno do Deficit de Atenção com Hiperatividade
/
Cérebro
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Child
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article