From Neanderthal to nanobiotech: from plant potions to pharming with plant factories.
Methods Mol Biol
; 483: 1-23, 2009.
Article
em En
| MEDLINE
| ID: mdl-19183890
ABSTRACT
Plants were the main source for human drugs until the beginning of the nineteenth century when plant-derived pharmaceuticals were partly supplanted by drugs produced by the industrial methods of chemical synthesis. During the last decades of the twentieth century, genetic engineering has offered an alternative to chemical synthesis, using bacteria, yeasts and animal cells as factories for the production of therapeutic proteins. After a temporary decrease in interest, plants are rapidly moving back into human pharmacopoeia, with the recent development of plant-based recombinant protein production systems offering a safe and extremely cost-effective alternative to microbial and mammalian cell cultures. In this short review, we will illustrate that current improvements in plant expression systems are making them suitable as alternative factories for the production of either simple or highly complex therapeutic proteins.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biotecnologia
/
Plantas Geneticamente Modificadas
/
Nanotecnologia
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article