Correcting aberrant kinetochore microtubule attachments: an Aurora B-centric view.
Curr Opin Cell Biol
; 21(1): 51-8, 2009 Feb.
Article
em En
| MEDLINE
| ID: mdl-19185479
ABSTRACT
The directed movement of chromosomes during mitosis and meiosis relies on microtubule-mediated connections between spindle poles and kinetochores assembled on chromosomes. The molecular basis for the dynamic interaction between microtubules and kinetochores is just beginning to be unveiled. Here, focusing on the mitotic centromere kinase Aurora B, we review our current understanding of the signaling pathways that correct erroneous microtubule attachment at kinetochores. We evaluate several potential models that may explain how maloriented attachments are recognized and processed by the Aurora B pathway.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Centrômero
/
Proteínas Serina-Treonina Quinases
/
Cinetocoros
/
Microtúbulos
Limite:
Animals
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article