Quassinoid inhibition of AP-1 function does not correlate with cytotoxicity or protein synthesis inhibition.
J Nat Prod
; 72(3): 503-6, 2009 Mar 27.
Article
em En
| MEDLINE
| ID: mdl-19199792
ABSTRACT
Several quassinoids were identified in a high-throughput screening assay as inhibitors of the transcription factor AP-1. Further biological characterization revealed that while their effect was not specific to AP-1, protein synthesis inhibition and cell growth assays were inconsistent with a mechanism of simple protein synthesis inhibition. Numerous plant extracts from the plant family Simaroubaceae were also identified in the same screen; bioassay-guided fractionation of one extract (Ailanthus triphylla) yielded two known quassinoids, ailanthinone (3) and glaucarubinone (4), which were also identified in the pure compound screening procedure.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inibidores da Síntese de Proteínas
/
Fator de Transcrição AP-1
/
Citotoxinas
/
Ailanthus
/
Quassinas
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article