FTICR-MS and LC-UV/MS-SPE-NMR applications for the rapid dereplication of a crude extract from the sponge Ianthella flabelliformis.
J Nat Prod
; 72(2): 290-4, 2009 Feb 27.
Article
em En
| MEDLINE
| ID: mdl-19206511
ABSTRACT
Dereplication of a methanolic extract of the marine sponge Ianthella flabelliformis using FTICR-MS accurate mass determination and MS(n) techniques enabled rapid and unambiguous detection of a new compound among a plethora of known compounds. Isolation of this compound and the known 19-deoxy analogue using the hyphenated technique LC-UV/MS-SPE-NMR was undertaken, and the structures were confirmed, from a single chromatographic run, as 19-hydroxyaraplysillin-I N(20)-sulfamate (1) and araplysillin-I N(20)-sulfamate (2).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poríferos
/
Cromatografia Líquida
/
Ressonância Magnética Nuclear Biomolecular
/
Hidrocarbonetos Bromados
/
Isoxazóis
Limite:
Animals
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article