KIR-HLA receptor-ligand mismatch associated with a graft-versus-tumor effect in haploidentical stem cell transplantation for pediatric metastatic solid tumors.
Pediatr Blood Cancer
; 53(1): 120-4, 2009 Jul.
Article
em En
| MEDLINE
| ID: mdl-19215002
ABSTRACT
Killer immunoglobulin-like receptors (KIRs) on natural killer cells (NKs) recognize groups of human leukocyte antigen (HLA) class I alleles. Cells without an inhibitory HLA ligand may trigger NK activation. Reduced risk of relapse has been reported in malignant hematologic diseases after haploidentical transplantation when HLA ligands against the inhibitory KIRs present in the donor were absent in the recipient. We performed haploidentical transplant in three children with refractory solid tumors. Our results showed that beneficial antitumor effects could be observed in the presence of inhibitory KIR-HLA mismatch. These preliminary results suggest a possible association between disease control and NK cell alloreactivity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Rabdomiossarcoma
/
Sarcoma de Ewing
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Neoplasias Ósseas
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Transplante de Células-Tronco Hematopoéticas
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Receptores KIR
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Rejeição de Enxerto
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Neuroblastoma
Tipo de estudo:
Risk_factors_studies
Limite:
Adolescent
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Child, preschool
/
Female
/
Humans
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Male
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article