Emergence of ciprofloxacin-resistant Neisseria meningitidis in North America.
N Engl J Med
; 360(9): 886-92, 2009 Feb 26.
Article
em En
| MEDLINE
| ID: mdl-19246360
ABSTRACT
We report on three cases of meningococcal disease caused by ciprofloxacin-resistant Neisseria meningitidis, one in North Dakota and two in Minnesota. The cases were caused by the same serogroup B strain. To assess local carriage of resistant N. meningitidis, we conducted a pharyngeal-carriage survey and isolated the resistant strain from one asymptomatic carrier. Sequencing of the gene encoding subunit A of DNA gyrase (gyrA) revealed a mutation associated with fluoroquinolone resistance and suggests that the resistance was acquired by means of horizontal gene transfer with the commensal N. lactamica. In susceptibility testing of invasive N. meningitidis isolates from the Active Bacterial Core surveillance system between January 2007 and January 2008, an additional ciprofloxacin-resistant isolate was found, in this case from California. Ciprofloxacin-resistant N. meningitidis has emerged in North America.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ciprofloxacina
/
Mutação Puntual
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Farmacorresistência Bacteriana
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Infecções Meningocócicas
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Anti-Infecciosos
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Neisseria meningitidis
Limite:
Adolescent
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Adult
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Aged
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Humans
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Infant
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Middle aged
País/Região como assunto:
America do norte
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article