Innovative applications for insect viruses: towards insecticide sensitization.
Trends Biotechnol
; 27(4): 190-8, 2009 Apr.
Article
em En
| MEDLINE
| ID: mdl-19251330
ABSTRACT
The effective management of emerging insect-borne disease is dependent on the use of safe and efficacious chemical insecticides. Given the inherent ability of insects to develop resistance, it is essential to propose innovative strategies because insecticides remain the most important element of integrated approaches to vector control. Recently, intracellular phosphorylation and dephosphorylation of membrane receptors and ion channels targeted by insecticides have been described as new processes for increasing the sensitivity of insecticides. An efficient method might be to infect host insects with recombinant viruses overexpressing specific protein phosphatases/kinases known to regulate specific insecticide-sensitive targets. This attractive strategy could lead to sensitization of the insects, thus reducing the doses of insecticides and increasing the efficacy of treatments.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Resistência a Inseticidas
/
Controle Biológico de Vetores
/
Controle de Insetos
/
Insetos Vetores
/
Vírus de Insetos
/
Inseticidas
/
Insetos
Limite:
Animals
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article