Amide analogs of antifungal dioxane-triazole derivatives: synthesis and in vitro activities.
Bioorg Med Chem Lett
; 19(7): 2013-7, 2009 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-19269821
ABSTRACT
A new series of triazole compounds possessing an amide-part were efficiently synthesized and their in vitro antifungal activities were investigated. The amide analogs showed excellent in vitro activity against Candida, Cryptococcus and Aspergillus species. The MICs of compound 23d against C. albicans ATCC24433, C. neoformans TIMM1855 and A. fumigatus ATCC26430 were 0.008, 0.031 and 0.031 microg/mL, respectively, (MICs of fluconazole 0.5, >4 and >4 microg/mL; MICs of itraconazole 0.125, 0.25, 0.25 microg/mL). Furthermore, compound 23d was stable under acidic conditions.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Triazóis
/
Benzamidas
/
Dioxanos
/
Amidas
/
Antifúngicos
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article