Positive associations between ionizing radiation and lymphoma mortality among men.
Am J Epidemiol
; 169(8): 969-76, 2009 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-19270049
ABSTRACT
The authors investigated the relation between ionizing radiation and lymphoma mortality in 2 cohorts 1) 20,940 men in the Life Span Study, a study of Japanese atomic bomb survivors who were aged 15-64 years at the time of the bombings of Hiroshima and Nagasaki, and 2) 15,264 male nuclear weapons workers who were hired at the Savannah River Site in South Carolina between 1950 and 1986. Radiation dose-mortality trends were evaluated for all malignant lymphomas and for non-Hodgkin's lymphoma. Positive associations between lymphoma mortality and radiation dose under a 5-year lag assumption were observed in both cohorts (excess relative rates per sievert were 0.79 (90% confidence interval 0.10, 1.88) and 6.99 (90% confidence interval 0.96, 18.39), respectively). Exclusion of deaths due to Hodgkin's disease led to small changes in the estimates of association. In each cohort, evidence of a dose-response association was primarily observed more than 35 years after irradiation. These findings suggest a protracted induction and latency period for radiation-induced lymphoma mortality.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cinza Radioativa
/
Monitoramento Ambiental
/
Exposição Ambiental
/
Armas Nucleares
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Linfoma
/
Guerra Nuclear
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Adolescent
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Adult
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
America do norte
/
Asia
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article