Your browser doesn't support javascript.
loading
t(3;9;22) 3-way chromosome translocation in chronic myeloid leukemia is associated with poor prognosis.
Tan, Jiahuai; Cang, Shundong; Seiter, Karen; Primanneni, Suneeta; Ahmed, Nasir; Mathews, Thomas; Liu, Delong.
Afiliação
  • Tan J; Department of Medicine, Mount Vernon Hospital, Mount Vernon, NY, USA.
Cancer Invest ; 27(7): 718-22, 2009 Aug.
Article em En | MEDLINE | ID: mdl-19308813
Chronic myelogenous leukemia (CML) is genetically characterized by the reciprocal translocation of chromosome 9 and 22. Around 5-8% of CML develop complex variant Ph translocations involving one or more chromosomal regions besides 9 and 22. Chromosome 3 is not frequently involved in complex translocations in CML. We report in this study a case of CML displaying a t(3;9;22) 3-way translocation. A review of the literature appears to indicate that CML patients with this translocation tend to have an aggressive course and poor outcome. Additional 3-way chromosome translocations associated with CML are also reviewed.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Translocação Genética / Cromossomos Humanos Par 3 / Cromossomos Humanos Par 9 / Cromossomos Humanos Par 22 / Leucemia Mieloide de Fase Crônica Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2009 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Translocação Genética / Cromossomos Humanos Par 3 / Cromossomos Humanos Par 9 / Cromossomos Humanos Par 22 / Leucemia Mieloide de Fase Crônica Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2009 Tipo de documento: Article