Improved synthesis of 3-substituted-4-amino-[3,2-c]-thienopyridines.
J Org Chem
; 74(10): 3849-55, 2009 May 15.
Article
em En
| MEDLINE
| ID: mdl-19371092
ABSTRACT
Two syntheses of 3-substituted-4-amino-[3,2-c]thienopyridines have been developed to replace the standard literature route to these compounds, which uses unattractive conditions involving azide and high temperatures. The first synthesis utilizes a Friedel-Crafts reaction as its key ring-forming step, whereas the second route relies on an unprecedented intramolecular reductive cyclization between a nitroolefin and a nitrile as its key ring-forming step. The development and optimization of each 3-substituted-4-amino-[3,2-c]thienopyridine synthesis is discussed and a comparison of the routes is presented.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piridinas
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article