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Molecular mechanisms controlling E-cadherin expression in breast cancer.
Baranwal, Somesh; Alahari, Suresh K.
Afiliação
  • Baranwal S; Department of Biochemistry and Molecular Biology, LSU Health Science Center, New Orleans, LA 70112, USA.
Biochem Biophys Res Commun ; 384(1): 6-11, 2009 Jun 19.
Article em En | MEDLINE | ID: mdl-19379710
Disruption of cell-cell adhesion, which is essential for the maintenance of epithelial plasticity and is mediated by a class of proteins called cadherins, is an initial event in the progression of cancer. Cadherins are Ca(2+)-dependent transmembrane proteins that are associated with actin via other cytoplasmic proteins. Disruption of cell-cell adhesion during cancer progression is an important event during cancer initiation and metastasis. E-cadherin, one of the most widely studied tumor suppressors in breast cancer, belongs to a family of calcium-dependent cell adhesion molecules. Various signaling molecules and transcription factors regulate the expression of E-cadherin. Loss of E-cadherin has been reported to induce epithelial-mesenchymal transition in several cancers. This review highlights recent advances in defining the mechanisms that regulate E-cadherin expression in breast cancer.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Caderinas / Regulação Neoplásica da Expressão Gênica Limite: Humans Idioma: En Ano de publicação: 2009 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Caderinas / Regulação Neoplásica da Expressão Gênica Limite: Humans Idioma: En Ano de publicação: 2009 Tipo de documento: Article