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Placental and fetal hemodynamics after labetalol or pindolol in a sheep model of increased placental vascular resistance and maternal hypertension.
Erkinaro, Tiina; Kavasmaa, Tomi; Ylikauma, Laura; Mäkikallio, Kaarin; Haapsamo, Mervi; Acharya, Ganesh; Ohtonen, Pasi; Alahuhta, Seppo; Räsänen, Juha.
Afiliação
  • Erkinaro T; Department of Anesthesiology, Oulu University Hospital, Finland. tiina.erkinaro@pp.fimnet.fi
Reprod Sci ; 16(8): 749-57, 2009 Aug.
Article em En | MEDLINE | ID: mdl-19380903
We investigated the effects of labetalol and pindolol on uterine, placental, and fetal hemodynamics following norepinephrine-induced maternal hypertension in a sheep model of increased placental vascular resistance. Also, we examined fetal and placental hemodynamic responses to acute hypoxemia after antihypertensive medication. Norepinephrine increased maternal heart rate (HR), mean arterial pressure (MAP) and uterine vascular resistance (R(UtA)), and decreased uterine volume blood flow (Q(UtA)). Both labetalol and pindolol decreased maternal HR, MAP, and R(UtA), but did not restore Q(UtA). Fetal MAP was unaffected while fetal HR and placental volume blood flow (Q(UA)) decreased and placental vascular resistance increased. During hypoxemia, which was induced by decreasing maternal inspiratory oxygen fraction, all these parameters remained unchanged in the labetalol group while fetal HR increased and Q(UA) further decreased in the pindolol group. We conclude that labetalol and pindolol may compromise uterine and placental hemodynamics. Hypoxemic stress provokes divergent hemodynamic responses in fetuses exposed to these differently acting adrenoceptor antagonists.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pindolol / Placenta / Resistência Vascular / Antagonistas Adrenérgicos beta / Feto / Hemodinâmica / Hipertensão / Labetalol / Anti-Hipertensivos Limite: Animals / Pregnancy Idioma: En Ano de publicação: 2009 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pindolol / Placenta / Resistência Vascular / Antagonistas Adrenérgicos beta / Feto / Hemodinâmica / Hipertensão / Labetalol / Anti-Hipertensivos Limite: Animals / Pregnancy Idioma: En Ano de publicação: 2009 Tipo de documento: Article