Delta-catenin regulates spine and synapse morphogenesis and function in hippocampal neurons during development.
J Neurosci
; 29(17): 5435-42, 2009 Apr 29.
Article
em En
| MEDLINE
| ID: mdl-19403811
ABSTRACT
The maintenance of spine and synapse number during development is critical for neuronal circuit formation and function. Here we show that delta-catenin, a component of the cadherin-catenin cell adhesion complex, regulates spine and synapse morphogenesis during development. Genetic ablation or acute knockdown of delta-catenin leads to increases in spine and synapse density, accompanied by a decrease in tetrodotoxin induced spine plasticity. Our results indicate that delta-catenin may mediate conversion of activity-dependent signals to morphological spine plasticity. The functional role of delta-catenin in regulating spine density does not require binding to cadherins, but does require interactions with PDZ domain-containing proteins. We propose that the perturbations in spine and synaptic structure and function observed after depletion of delta-catenin during development may contribute to functional alterations in neural circuitry, the cognitive deficits observed in mutant mice, and the mental retardation pathology of Cri-du-chat syndrome.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfoproteínas
/
Sinapses
/
Moléculas de Adesão Celular
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Espinhas Dendríticas
/
Hipocampo
/
Morfogênese
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Neurônios
Limite:
Animals
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article