Dynamics of membrane trafficking downstream of B and T cell receptor engagement: impact on immune synapses.
Traffic
; 10(6): 629-36, 2009 Jun.
Article
em En
| MEDLINE
| ID: mdl-19416472
ABSTRACT
The onset of an adaptive immune response requires the activation of T and B lymphocytes by antigen-presenting cells, through a specialized form of intercellular communication, known as the immunological synapse (IS). In B lymphocytes the IS promotes efficient recognition and acquisition of membrane-bound Ags, while in T cells, it modulates the T cell response upon exposure to peptide-major histocompatibility complexes. In this review, we highlight the similarities that determine B and T cell activation, focusing on immune receptor downstream signaling events that lead to synapse formation. We stress the notion that polarization of T and B lymphocytes characterized by global changes in cytoskeleton and membrane trafficking modulates synapse structure and function, thus determining lymphocyte effector functions and fate.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de Antígenos de Linfócitos B
/
Receptores de Antígenos de Linfócitos T
/
Sinapses Imunológicas
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article