APOE 4 polymorphism results in early cognitive deficits in an EAE model.
Biochem Biophys Res Commun
; 384(4): 466-70, 2009 Jul 10.
Article
em En
| MEDLINE
| ID: mdl-19422789
ABSTRACT
Recent clinical studies have identified an association between APOE 4 and cognitive deficits in patients with multiple sclerosis. We induced experimental autoimmune encephalomyelitis (EAE) in APOE knockout (KO) and human APOE 4 knockin (E4) mice to study the interaction of APOE and neuroinflammation on cognition. After EAE induction, KO and E4 showed significant deficits in spatial learning and recall. Regional decreases in choline acetyltransferase localized to the hippocampus. Induction of EAE in a transgenic APOE animal provides a template from which we can decipher the role APOE has on cognition in the context of neuroinflammation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Comportamento Espacial
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Transtornos Cognitivos
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Encefalomielite Autoimune Experimental
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Apolipoproteína E4
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Memória
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Esclerose Múltipla
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article