The role of the p75 neurotrophin receptor in cholinergic dysfunction in Alzheimer's disease.
Neuroscientist
; 15(4): 317-23, 2009 Aug.
Article
em En
| MEDLINE
| ID: mdl-19458382
ABSTRACT
Degeneration of basal forebrain cholinergic neurons is a common feature of Alzheimer's disease and is proposed to be an early and key event in the condition's etiology. This review discusses recent findings that strongly link the p75 neurotrophin receptor (p75(NTR)) to both cholinergic neuron degeneration and the production of toxic forms of amyloid-beta (Abeta), which is found deposited as amyloid plaques in the brains of Alzheimer's disease patients. Although elucidating the underlying molecular mechanisms and the clinical significance of these findings will require further experimentation, a number of possible scenarios and future research directions are presented.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Acetilcolina
/
Fibras Colinérgicas
/
Receptor de Fator de Crescimento Neural
/
Doença de Alzheimer
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article