[S-1 activity in non-small cell lung cancer in clinical practice].
Gan To Kagaku Ryoho
; 36(5): 763-7, 2009 May.
Article
em Ja
| MEDLINE
| ID: mdl-19461174
ABSTRACT
OBJECTIVE:
We evaluated retrospectively single-agent S-1 chemotherapy in non-small cell lung cancer patients in clinical practice.METHODS:
Sixteen consecutive patients treated with single-agent S-1 for NSCLC between July 2005 and June 2007 at the Department of Thoracic Surgery, Tsuchiura Kyodo General Hospital. The treatment schedule comprised oral administration of S-1 at 80-120 mg/day. One cycle of S-1 consisted of consecutive administration to 14 (10 cases)or 28(6 cases)days followed by a 14-day rest.RESULTS:
Patients profiles were M/F 11/5, median age 68 years old(range 51-83), PS 0/1/2/3 2/6/5/3, adeno/squamous/large 13/2/1, clinical stage 3A/3B/4 3/4/9, prior chemotherapy regimens 0/1/2/3/4 2/3/4/5/2, prior surgery/radiation 12/5 were performed. Median number of delivered cycles was 5 cycles(range 1-13). Grade 3 hematological toxicities were anemia(6%)and thrombocytopenia(6%). Grade 3 non-hematological toxicities were nausea(6%)and vomiting(6%). Response of 13 patients could be evaluated after 2-4 cycles of S-1. Four partial responses were observed, for a response rate of 31%. The survival time was 67-852 days(average 14.0 months), 1-year survival rate was 74.0%, median time to progression was 4.6 m, and 1- year progression free survival was 25.0%.CONCLUSION:
Single-agent S-1 chemotherapy has modest activity and is the one of the important regimens and tolerable for elderly, poor-PS, recurrent patients with NSCLC in clinical practice.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Oxônico
/
Protocolos de Quimioterapia Combinada Antineoplásica
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Tegafur
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Carcinoma Pulmonar de Células não Pequenas
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Neoplasias Pulmonares
Limite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
Ja
Ano de publicação:
2009
Tipo de documento:
Article