Rhodium-catalyzed 1,4-additions to enantiopure acceptors: asymmetric synthesis of functionalized pyrrolizidinones.
Org Lett
; 11(12): 2491-4, 2009 Jun 18.
Article
em En
| MEDLINE
| ID: mdl-19462943
ABSTRACT
The rhodium-catalyzed 1,4-addition of arylboronic acids to an enantiopure heterocyclic acceptor proceeds under ligand control to effect an asymmetric synthesis of functionalized pyrrolizidinones. The protocol allows convenient access to all four stereoisomers of pyrrolizidinone 3a (Ar = Ph) by appropriate selection of substrate and catalyst.
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01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article