Arachidonic acid metabolites and colchicine in Behçet's disease (BD).
Prostaglandins Leukot Essent Fatty Acids
; 43(4): 257-9, 1991 Aug.
Article
em En
| MEDLINE
| ID: mdl-1946553
ABSTRACT
Vasculitis is accepted to be the basis of Behçet's disease (BD) which is a multisystem disease, and the arachidonic acid(AA) metabolites acting as balancing mediators in the organism are accepted to be responsible for the vasculitis. In this study, we examined the prostaglandin E2 (PGE2) and leukotriene C4 (LTC4) levels of the patients with BD before and after colchicine therapy. We found a statistical decrease in the PGE2 and LTC4 levels after colchicine therapy compared to the previous levels, concluding that colchicine inhibits the inflammation and the polymorphonuclear leukocyte (PML) chemotaxis by inhibiting the cyclooxygenase and lipoxygenase pathways.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Colchicina
/
Síndrome de Behçet
/
Ácido Araquidônico
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article