Effects of a dairy product (pecorino cheese) naturally rich in cis-9, trans-11 conjugated linoleic acid on lipid, inflammatory and haemorheological variables: a dietary intervention study.
Nutr Metab Cardiovasc Dis
; 20(2): 117-24, 2010 Feb.
Article
em En
| MEDLINE
| ID: mdl-19473822
ABSTRACT
BACKGROUND AND AIM:
Some studies recently reported a favourable effect for cis-9, trans-11 conjugated linoleic acid (CLA) on plasma lipoprotein profile of healthy subjects. Aim of this crossover intervention study was to evaluate the influence of a short-term dietary intake of a cheese derived from sheep's milk naturally rich in CLA on several atherosclerotic biomarkers, in comparison with a commercially available cheese. METHODS ANDRESULTS:
Ten subjects (6 F; 4 M) with a median age of 51.5 followed for 10 weeks a diet containing 200 g/week of cheese naturally rich in CLA (intervention period) and for the same period a diet containing a commercially available cheese of the same quantity (placebo period). Consumption of the dairy product naturally rich in cis-9, trans-11 CLA determined a significant (p<0.05) reduction in inflammatory parameters such as interleukin-6 (pre 8.08+/-1.57 vs. post 4.58+/-0.94 pg/mL), interleukin-8 (pre 45.02+/-5.82 vs. post 28.59+/-2.64 pg/mL), and tumour necrosis factor-alpha (pre 53.58+/-25.67 vs. post 32.09+/-17.42 pg/mL) whereas no significant differences in the placebo period were observed. With regard to haemorheological parameters, the test period significantly ameliorated erythrocytes' filtration rate (pre 7.61+/-0.71% vs. post 9.12+/-0.97%; p=0.03) with respect to the placebo period. Moreover, a reduction in the extent of platelet aggregation, induced by arachidonic acid [pre 87.8+/-1.76% vs. post 77.7+/-3.56%; p=0.04] was observed during the test period in comparison with the placebo period.CONCLUSIONS:
Dietary short-term intake of the tested dairy product naturally rich in cis-9, trans-11 CLA appeared to cause favourable biochemical changes of atherosclerotic markers.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Queijo
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Hemorreologia
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Mediadores da Inflamação
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Ácidos Linoleicos Conjugados
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Lipídeos
Tipo de estudo:
Clinical_trials
Limite:
Animals
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article